The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis
김재붕, 정미화, 조제열, 박진우, 서조영, 이재목,
소속 상세정보
김재붕 ( Kim Jae-Bung ) - Kyungpook National University School of Dentistry Department of Periodontology
정미화 ( Jung Mi-Hwa ) - Kyungpook National University School of Dentistry Department of Periodontology
조제열 ( Cho Je-Yeol ) - Kyungpook National University School of Dentistry Department of Oral Biochemistry
박진우 ( Park Jin-Woo ) - Kyungpook National University School of Dentistry Department of Periodontology
서조영 ( Suh Jo-Young ) - Kyungpook National University School of Dentistry Department of Periodontology
이재목 ( Lee Jae-Mok ) - Kyungpook National University School of Dentistry Department of Periodontology
KMID : 0363020110410030109
Abstract
Purpose: The purpose of this study was to compare and quantify the expression of C-reactive protein (CRP), matrix metalloproteinase (MMP)-14, and tissue inhibitor of metalloproteinases (TIMP)-2 in gingival tissues of patients with chronic periodontitis accompanied with inflammatory reaction related to alveolar bone resorption with or without type 2 diabetes mellitus (DM).
Methods: Twelve patients with type 2 DM and chronic periodontitis (group 3), twelve patients with chronic periodontitis (group 2), and twelve healthy individuals (group 1) were included in the study. Gingival tissue biopsies were collected from each patient and from healthy individuals at the time of periodontal surgery (including surgical crown lengthening) or tooth extraction. The concentrations of cytokines were determined by a western blot analysis.
Results: The expression levels of CRP and MMP-14 increased in group 2 and 3, and they were highest in group 3. The expressions of TIMP-2 also increased in group 2 and 3.
Conclusions: This study demonstrated that the expression levels of CRP, MMP-14, and TIMP-2 might be inflammatory markers in periodontal inflamed tissue. It can be assumed that CRP, MMP-14, and TIMP-2 may be partly involved in the progression of periodontal inflammation associated to type 2 DM.
키워드
Chronic periodontitis; Type 2 diabetes mellitus; C-reactive protein; Matrix metalloproteinase 14; Tissue inhibitor of metalloproteinase-2
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